521 Cell Cycle Regulation Changes in Drug-Resistant Cancers
نویسندگان
چکیده
منابع مشابه
Cell cycle regulation and anticancer drug discovery
Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent kinase (CDK)-cyclin complexes, checkpoint kinases, and CDK inhibitors. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, severa...
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Cell division plays a crucial role during a11 phases of plant development. Continuing organogenesis and plastic growth responses to a changing environment require precise spatial, temporal, and developmental regulation of cell division activity in meristems. The molecular analysis of cell division and its regulation in plants lags far behind such studies in yeast and animals. Since the cell the...
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Cell-division control affects many aspects of development. Caenorhabditis elegans cell-cycle genes have been identified over the past decade, including at least two distinct Cyclin-Dependent Kinases (CDKs), their cyclin partners, positive and negative regulators, and downstream targets. The balance between CDK activation and inactivation determines whether cells proceed through G1 into S phase,...
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ژورنال
عنوان ژورنال: European Journal of Cancer
سال: 2012
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(12)72318-3